447C88

447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia[1][2].

130400-16-7

12352005

Acyltransferase

Metabolic Enzyme/Protease

Endocrinology; Metabolic Disease

O=C(NCCCCCCC)NC1=C(F)C=C(F)C=C1CCC2=CC=C(CC(C)(C)C)C=C2

C27H38F2N2O

444.60

[1]Fraser IJ, et al. Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry. J Chromatogr B Biomed Appl. 1995 Jan 20;663 (2) :275-87.|[2]Peck RW, et al. The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur J Clin Pharmacol. 1995;49 (3) :243-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19112/

Reference compound1

Phase 1

ACAT