4E-BP1 (fosfo Thr70) Antilichaam

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

1978

Q13541

NP_004086.1

Human

4E-BP1 (phospho Thr70) antibody was raised against a peptide sequence around phosphorylation site of threonine70 (T-K-T (p) -P-P) derived from Human 4E-BP1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

12 kDa

IgG

The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.

EIF4EBP1

Eukaryotic translation initiation factor 4E binding protein 1

Homo sapiens

Pause A., Nature 371:762-767 (1994) .

Gevaert K., Nat. Biotechnol. 21:566-569 (2003) .

Haghighat A., EMBO J. 14:5701-5709 (1995) .

4EBP1, P/OKCL.6, P/OKCL.6, PHAS-I

IHC

4758258

Liquid