5- (2-Chlooraceetamide) thalidomide
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
5- (2-Chloroacetamide) thalidomide is a Thalidomide analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.
1957235-51-6
12352005
H302, H314
Ligands for E3 Ligase
PROTAC
Cancer-programmed cell death
Cancer
95.0
ClCC(NC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O
C15H12ClN3O5
349.73
H302, H314
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W674381/5-2-Chloroacetamide-thalidomide-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
5- (2-Chloroacetamide) thalidomide is a Thalidomide analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given prot
Specificaties
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