5-Acetamide-butenolide

5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells[1][2][3].

16275-44-8

Butenolide

12352005

H315-H319-H335

Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Metabolism-sugar/lipid metabolism

Metabolic Disease

O=C1OC(NC(C)=O)C=C1

C6H7NO3

141.12

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

[1]Yates S G, et al. Mycotoxins produced by Fusarium nivale isolated from tall fescue (Festuca arundinacea Schreb.) [J]. Phytochemistry, 1968, 7 (1) : 139-146.|[2]Wang YM, et al. Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. Toxicol Mech Methods. 2009 Feb;19 (2) :79-85.|[3]Wang YM, et al. Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. Toxicol Lett. 2006 Jul 14;164 (3) :231-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W402074/

Reference compound1

No Development Reported