5-AIQ (hydrochloride)

5-AIQ hydrochloride is a PARP-1 inhibitor. 5-AIQ hydrochloride is an important functional group in various drugs. 5-AIQ hydrochloride reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver[1][2].

93117-07-8

5-Aminoisoquinolin-1-one (hydrochloride)

12352005

H315-H319-H335

PARP

Cell Cycle/DNA Damage; Epigenetics

Cancer-programmed cell death

Cancer

O=C1NC=CC2=C1C=CC=C2N.Cl

C9H9ClN2O

196.63

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

[1]Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20 (2) :90-5.|[2]Mota-Filipe H, et al. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8 (11) :BR444-53.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W006566A/

Reference compound1

No Development Reported