5α-androstan-3α-ol

5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor) . 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms[1].

7657-50-3

3α,5α-Androstanol

12352211

H302-H315-H319-H335

Constitutive Androstane Receptor; GABA Receptor

Membrane Transporter/Ion Channel; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Metabolism-protein/nucleotide metabolism

Metabolic Disease

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C

C19H32O

276.46

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Kliewer SA, et al. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999 Apr 30;284 (5415) :757-60.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W722556/

Reference compound2

No Development Reported