5-fluororotisch zuur (standaard)

5-Fluoroorotic acid is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid exhibits antimalarial activity[1][2][3].

703-95-7

12352005

Parasite; Thymidylate Synthase

Anti-infection; Apoptosis

Infection

O=C(C(NC1=O)=C(F)C(N1)=O)O

C5H3FN2O4

174.09

[1]Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75.|[2]Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9 (2) : 85-9.|[3]Santoso D, et al., Fluoroorotic acid-selected Nicotiana plumbaginifolia cell lines with a stable thymine starvation phenotype have lost the thymine-regulated transcriptional program. Plant Physiol. 2000 Aug;123 (4) :1517-24.|[4]Rathod PK, et al., Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1989 Jul;33 (7) :1090-4. |[5]Gómez ZM, et al., Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. Antimicrob Agents Chemother. 1990 Jul;34 (7) :1371-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W016819R/

Reference Standards