5-fluoruridine-5'-fosfaat

5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 µM for human ODCase and a Ki value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research [1].

796-66-7

12352005

H302, H315, H319, H335

DNA/RNA Synthesis

Cell Cycle/DNA Damage

Cancer-programmed cell death

Cancer

98.56

H2O : 100 mg/mL (ultrasonic)

O=C(N1)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=C(F)C1=O

C9H12FN2O9P

342.17

H302, H315, H319, H335

[1]Bello AM, et al. Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52 (6) :1648-58.

Blue Ice

-20°C (Powder, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-W784565/5-Fluorouridine-5-phosphate-SDS-MedChemExpress.pdf

Oligonucleotides

No Development Reported