5-Hydroxyindool (standaard)

5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole. This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders[1][2][3][4][5][6][7].

1953-54-4

12352005

Calcium Channel; Endogenous Metabolite; nAChR; Reference Standards

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Cancer; Endocrinology; Neurological Disease

OC1=CC2=C(C=C1)NC=C2

C8H7NO

133.15

[1]Kooyman AR, et, al. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells. Br J Pharmacol. 1993 Feb;108 (2) :287-9.|[2]LaPorte M, et, al. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. J Org Chem. 2013 Jan 4;78 (1) :167-74.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W001160R/

Reference Standards

L-type calcium channel; Microbial Metabolite