5-Hydroxysaxagliptine (hydrochloride)

5-Hydroxy saxagliptin hydrochloride is an active metabolite of Saxagliptin and a potent and selective DPP-4 inhibitor. 5-Hydroxy saxagliptin hydrochloride has Ki values of 2.6 nM and 2.9 nM for humans and cynomolgus monkeys, respectively. 5-Hydroxy saxagliptin hydrochloride can be used in the research of type 2 diabetes mellitus[1].

12352005

Dipeptidyl Peptidase

Metabolic Enzyme/Protease

Metabolic Disease

O[C@@]1(C2)C[C@@]3([C@@H](C(N4[C@H](C#N)C[C@H]5[C@@H]4C5)=O)N)C[C@@](C[C@@H]2C3)(O)C1.Cl

C18H26ClN3O3

367.87

[1]Wang A, et al. Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor. BMC Pharmacol. 2012 Apr 4;12:2.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W741755A/

Reference compound1

No Development Reported

DPP-4; DPP-8; DPP-9