5-Iodouracil

5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM) . 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC) [1].

696-07-1

12352005

H302+H312+H332, H315, H319, H335

Dihydropyrimidine Dehydrogenase (DPD)

Metabolic Enzyme/Protease

Cancer

99.95

O=C1NC=C(I)C(=O)N1

C4H3IN2O2

237.98

H302+H312+H332, H315, H319, H335

[1]Hattori K, et al. Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett. 2003 Mar 10;13 (5) :867-72.

Room Temperature

4°C (Powder, protect from light)

http://file.medchemexpress.com/batch_PDF/HY-W001983/5-Iodouracil-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported