53BP1 Konijn mAb (AMR11533N)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub and histone H4 dimethylated at 'Lys-20' (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V (DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality 53BP1 Rabbit mAb (AMR11533N) .
53BP1; TDRD30; TP53; p202; p53BP1
7158
Q12888
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Liquid
Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Calculated MW: 450kDa Observed MW: 450KDa
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7158
https://www.uniprot.org/uniprot/Q12888
Email for sequence
Beschrijving
53BP1 Konijn mAb (AMR11533N) Beschikbaar in 50 µL. Bestel eenvoudig online met snelle levering.
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