5,6-Dihydro-2H-pyran-2-on

5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type carbonic anhydrase inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with Ki values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer[1].

3393-45-1

12352005

H226

Carbonic Anhydrase

Metabolic Enzyme/Protease

Cancer

99.19

O=C1OCCC=C1

C5H6O2

98.10

H226

[1]Carta F, et al. 5- and 6-membered (thio) lactones are prodrug type carbonic anhydrase inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :267-70.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W044762/

Reference compound2

No Development Reported

CA I; CA IX