6

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.

Il6; Il-6

16193

P08505

NP_112445.1

NM_031168

5 B1; 5 17.0 cM

Mouse

Monkey, Mouse, Rat, Trout

MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & Coomassie stain

The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/ml.

188

Lyophilized

50 mM Acetic Acid

50 mM Acetic Acid

21.7 kDa

E. coli

MFPTS