6-Chloor-7-deazaguanine

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively[1].

84955-31-7

12352005

H319

IKK

NF-κB

Cancer

99.83

H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

NC1=NC(Cl)=C2C(NC=C2)=N1

C6H5ClN4

168.58

H319

[1]Anthony NG, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, Gamble C, Gray AI, Harvey AL, Hatziieremia S, Ho KH, Huggan JK, Lang S, Llona-Minguez S, Luo JL, McIntosh K, Paul A, Plevin RJ, Robertson MN, Scott R, Suckling CJ, Sutcliffe OB, Young LC, Mackay SP. Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers. J Med Chem. 2017 Aug 24;60 (16) :7043-7066.

Blue Ice

-20°C (Powder, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-69047/6-Chloro-7-deazaguanine-SDS-MedChemExpress.pdf

Reference compound1

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