6-Thioguanine
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1) .2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
Unconjugated
Pale yellow solid
-20°C
Beschrijving
6-Thioguanine Beschikbaar in 100 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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