6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatrieen

6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene (Compound 6) is a diterpenoid found in Premna obtusifolia. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene exhibits antibacterial against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-resistant Enterococcus faecalis (VRE) (MIC = 37.5 μg/mL) . 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can significantly inhibit the release of the inflammatory mediator NO, with an IC50 value of 29.1 μM. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can be used for the researches of infection and inflammation[1].

1353042-00-8

12352005

Bacterial

Anti-infection

Infection; Inflammation/Immunology

OC1=C2[C@@]34[C@@](C(C)(CCC4)C)([H])[C@H]([C@@](OC3)([H])C2=CC(C(C)C)=C1O)O

C20H28O4

332.43

[1]Abdul-Wahab Salae; et al. Potential anti-inflammatory diterpenes from Premna obtusifolia. , 68 (3), 819–829.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16665/

Natural Products

No Development Reported