7-Dezaxanthine

7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase) . 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect[1].

39929-79-8

7DX

12352005

H302, H315, H319, H335

Thymidylate Synthase

Apoptosis

Neuroscience-Neurodegeneration

Cardiovascular Disease

99.72

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

O=C1NC(C2=C(N1)NC=C2)=O

C6H5N3O2

151.12

H302, H315, H319, H335

[1]Balzarini J, et al. 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. FEBS Lett. 1998 Oct 30;438 (1-2) :91-5.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-77537/7-Deazaxanthine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported