7-Hydroxychloorpromazine (hydrochloride)

7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine. 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis[1][2].

51938-11-5

12352005

H301-H330

Dopamine Receptor; Drug Metabolite

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Neurological Disease

ClC1=CC=C2SC3=CC(O)=CC=C3N(CCCN(C)C)C2=C1.Cl

C17H20Cl2N2OS

371.32

P260-P264-P270-P271-P284-P304+P340-P330-P403+P233-P405-P501

[1]Meltzer H Y, et al. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats[J]. European Journal of Pharmacology, 1977, 41 (4) : 431-436.|[2]Perry T L, et al. 7-Hydroxychlorpromazine: potential toxic drug metabolite in psychiatric patients[J]. Science, 1964, 146 (3640) : 81-83.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W704749/

Reference compound1

No Development Reported