7,8,9,10-Tetrahydrobenzo[proxy]tetrafen-7-ol

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters[1], which are capable of forming covalent DNA adducts and inducing mutations[2].

6272-55-5

12352005

H302, H315, H319, H332, H335

Biochemical Assay Reagents

Others

Cancer-programmed cell death

Cancer

98.09

DMSO : 250 mg/mL (ultrasonic)

OC1CCCC2=C3C=CC4=CC=CC5=C4C3=C(C=C21)C=C5

C20H16O

272.35

H302, H315, H319, H332, H335

[1]Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 1994 Nov;15 (11) :2605-11.|[2]Surh YJ, Tannenbaum SR. Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene. Chem Res Toxicol. 1995 Jul-Aug;8 (5) :693-8.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W011640/7-8-9-10-Tetrahydrobenzo-pqr-tetraphen-7-ol-SDS-MedChemExpress.pdf

Reference compound1

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