9,10-Fenantreenchinon

9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis[1].

84-11-7

12352005

H319, H400

Claudin

Cytoskeleton

Cancer-programmed cell death

Cancer

99.95

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

O=C1C2=CC=CC=C2C3=CC=CC=C3C1=O

C14H8O2

208.21

H319, H400

[1]Kamase K, et al. 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology. 2021 Sep;461:152896.

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W014507/9-10-Phenanthrenequinone-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported