
A-769662
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the and subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
Unconjugated
Beige solid
-20°C
Beschrijving
A-769662 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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