Aβ-aggregatie-IN-1
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fibrillogenesis with IC50 values of 3.92 and 7.19 M, respectively. Aβ aggregation-IN-1 also inhibits malondialdehyde formation, augments the intracellular reduced glutathione (GSH) levals and inhibits caspase 3 in neuronal cells[1].
352525-91-8
12352005
H315, H319, H335
Amyloid-β
Neuronal Signaling
Neurological Disease
99.92
DMSO : 100 mg/mL (ultrasonic)
FC(F)(F)C1=CC=C(/C=C/B(O)O)C=C1
C9H8BF3O2
215.97
H315, H319, H335
[1]Jiménez-Aligaga K, et al. Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :426-9.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W117986/Aβ-aggregation-IN-1-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fi
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