A Synucleïne (Ab 136) Antilichaam

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

20617

P37840

NP_001035916.1

Mouse, Rat

A-Synuclein (Ab-136) antibody was raised against a peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Mouse α -Synuclein.

Unconjugated

Primary Antibodies

Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

18 kDa

This antibody detects endogenous level of total α -Synuclein protein.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Snca

Synuclein, alpha

This antibody was raised against a peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Mouse α -Synuclein.

Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

NACP, alphaSYN, NACP, SYN, SYUA, alpha-synuclein

WB, IF

109638747

Liquid