A Synucleïne (fosfo Tyr125) Antilichaam

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

6622

P37840

NP_000336.1

Human

A-Synuclein (Phospho-Tyr125) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y (p) -E-M) derived from Human α -Synuclein.

Unconjugated

Primary Antibodies

Phospho-Specific, Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

18 kDa

This antibody detects endogenous level of α -Synuclein only when phosphorylated at tyrosine 125.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

SNCA

Synuclein, alpha (non A4 component of amyloid precursor)

Homo sapiens

Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

PD1, NACP, PARK1, PARK4, CD135, FLK2, STK1, SYN, SYUA, alpha-synuclein

WB, IF

4507109

Liquid