A Synucleïne (fosfo-Tyr136) Antilichaam

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

6622

P37840

NP_000336.1

Human, Mouse, Rat

A-Synuclein (Phospho-Tyr136) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 136 (Q-D-Y (p) -E-P) derived from Human α -Synuclein.

Unconjugated

Primary Antibodies

Phospho-Specific, Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

18 kDa

This antibody detects endogenous level ofα -Synuclein only when phosphorylated at tyrosine 136.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

SNCA

Synuclein, alpha (non A4 component of amyloid precursor)

Homo sapiens

Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

PD1, NACP, PARK1, PARK4, FAK, FAK1, SYN, SYUA

WB, IF

4507109

Liquid