A13:B7-24-GG

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation[1].

3057097-31-8

12352209

RXFP Receptor

GPCR/G Protein

Metabolic Disease

[H]N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C)C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(O)=O)CSSC[C@H](N1)C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)CCCNC(N)=N)=O)CO)=O)=O)=O)=O)CC(C)C)=O)=O)CO)=O)CC(C)C)=O)=O)CCCCN)=O)=O)CO)=O)=O)=O)=O)[C@@H](C)O)=O)CSSC[C@H](N[H])C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H]([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H]([C@H](CC)C)C1=O)=O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O

C149H236N40O47S5

3500.03

[1]Wang MD, et al. Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death. J Am Chem Soc. 2024 Oct 23;146 (42) :28669-28676.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11246/

Peptides

No Development Reported