AB Antilichaam

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

9131

O95831

Human

A synthetic peptide of human AIF

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C. Avoid freeze / thaw cycles.

Observed: 60kDa

IgG

AIFM1

Apoptosis inducing factor mitochondria associated 1

Homo sapiens

AIF Antibody: CNK, KSR, CNK1, Connector enhancer of kinase suppressor of ras 1, CNK homolog protein 1, Connector enhancer of KSR 1

WB, IHC, IF, Flow

Liquid