ABCA7 Antilichaam

ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

10347

Q8IZY2

NP_061985

Human

Unconjugated

Primary Antibodies

Homeostasis

ABCA7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ABCA7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.

ABCA7

Cat. No. 10-901 - Human Spleen Tissue Slide

Cat. No. 17-010 - HEK293 Cell Slide

ATP-binding cassette, sub-family A (ABC1), member 7

Homo sapiens

Kaminski WE, Orsó E, Diederich W, et al. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) . Biochem. Biophys. Res. Commun. 2000; 273:532-8.

Abe-Dohmae S, Ueda K, and Yokoyama S. ABCA7, a molecule with unknown function. FEBS Lett. 2006; 580:1178-82

Ikeda Y, Abe-Dohmae S, Munehira Y, et al. 2003. Post-transcriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem. Biophys. Res.Commun. 311:313-8.

Iwamoto N, Abe-Dohmae S, Sato R, et al. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J. Lipid Res. 2006; 47:1915-27.

ABCA7 Antibody: ABCX, ABCA-SSN, ATP-binding cassette sub-family A member 7

ELISA, WB, IHC-P, ICC, IF

150417984

Liquid