ABCB7 Antilichaam

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X) (q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

22

O75027

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 503-753 of human ABCB7 (NP_004290.2) .

Unconjugated

Primary Antibodies

Signal Transduction, Stem Cell

Affinity purification

A-431

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 83kDa

IgG

ABCB7

293T

Mouse heart

ATP-binding cassette, sub-family B (MDR/TAP), member 7

Homo sapiens

ABCB7, ABC transporter 7 protein, ABC7, Atm1p, ATP-binding cassette 7, ASAT, EST140535

WB, IHC, IF

Liquid