ABCB7 (NM 004299) Humaan Recombinant eiwit

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X) (q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 7 (ABCB7), nuclear gene encoding mitochondrial protein, Val431-End, with N-terminal His tag, expressed in E. coli, 50ug

ABC7; ASAT; Atm1p; EST140535

22

O75027, A0A0S2Z2Z3

NM_004299

Xq13.3

E. coli

N-His

ABC transporters

ABC transporters

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome, Transmembrane

35.8 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

ABCB7

Human

NP_004290

https://www.ncbi.nlm.nih.gov/gene/22

https://www.uniprot.org/uniprot/O75027

https://www.ncbi.nlm.nih.gov/nuccore/NM_004299

https://www.ncbi.nlm.nih.gov/nuccore/NP_004290