ABCC1 Antilichaam - middengebied: FITC (ARP43653 P050-FITC)

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

MRP, ABCC, GS-X, MRP1, ABC29, DFNA77

4363

P33527

NP_004987

Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human ABCC1

ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

UBC; ABCC1; CAV1; TRAF3; NPM1; AZGP1; STT3B; RAVER1; MCU; MRPL17; TMCO1; ATP6V1H; TMX2; TMOD2; NDUFAF3; FKBP8; PUF60; PGRMC2; FLOT1; PDCD6IP; ATP6V1F; EIF3C; PDHX; VDAC3; SURF1; STX4; SAFB; RPS7; NDUFB9; DBT; TMEM173; UNC93B1

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 77%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 93%; Rat: 85%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

171kDa

Nabekura, T., (2008) Biochem. Biophys. Res. Commun. 369 (2), 363-368

Wet Ice

1531

ABCC1

ABCC1

Rabbit

Multidrug resistance-associated protein 1

NM_004996

LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGA