Abemaciclib-d5
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib[2][3].
1809251-51-1
LY2835219-d5
12352005
Isotope-Labeled Compounds
Others
Cancer
CC(N1C(C)C)=NC(C1=CC(C2=C(C=NC(NC3=CC=C(CN4CCN(C([2H])(C([2H])([2H])[2H])[2H])CC4)C=N3)=N2)F)=C5)=C5F
C27H27D5F2N8
511.62
[1]Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7 (12) :14803-13.|[2]Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13 (10) :2253-63.|[3]Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs. 2014 Oct;32 (5) :825-37.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W728130/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib[2][3].
Specificaties
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