ABI-274
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib. ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma[1].
1253697-93-6
12352005
H302-H315-H319-H335
Microtubule/Tubulin
Cell Cycle/DNA Damage; Cytoskeleton
Cancer-programmed cell death
Cancer
COC1=CC(C(C2=CN=C(C3=CC=C(C=C3)C)N2)=O)=CC(OC)=C1OC
C20H20N2O4
352.38
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Wang, J., et al., (2014) . Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Molecular cancer therapeutics, 13 (1), 16-26.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W674149/
Reference compound1
No Development Reported
Beschrijving
ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib. ABI-27
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