ABL1 (fosfo Thr735) Antilichaam

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

25

P00519

NP_005148.2

Human, Mouse, Rat

ABL1 (phospho Thr735) antibody was raised against a peptide sequence around phosphorylation site of threonine735 (S-V-T (p) -L-P) derived from Human ABL1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

135 kDa

IgG

The antibody detects endogenous levels of ABL1 only when phosphorylated at threonine 735.

Western Blot: 1:500~1:1000

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Homo sapiens

Fainstein E., Oncogene 4:1477-1481 (1989) .

Shtivelman E., Cell 47:277-284 (1986) .

Chissoe S.L., Genomics 27:67-82 (1995) .

Abelson murine leukemia viral oncogene 1, ABL1, c-ABL, JTK7, p150

WB

62362414

Liquid