ABL1 Y253F Recombinant humaan actief eiwit Kinase
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate binding capacity, thus contributing to Imatinib Mesylate resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML). ABL1 Y253F Recombinant Human Active Protein Kinase is a recombinant ABL1 Y253F protein that can be used to study ABL1 Y253F-related functions[1].
12352211
Bcr-Abl
Protein Tyrosine Kinase/RTK
Cancer
[ABL1Y253FRecombinantHumanActiveProteinKinase]
[1]Yusoff YM, et al. Identification of novel BCR::ABL1 kinase domain mutation in patients with chronic myeloid leukaemia and imatinib resistance. Malays J Pathol. 2024 Dec;46 (3) :431-439.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-E70641/
Enzyme
No Development Reported
Beschrijving
The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate binding capacity, thus contributing to Imatinib Mesylate resistance. Id
Specificaties
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