ABL2 Antilichaam [1H1B11]

ABL2 (ARG, Abelson-related gene) is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. c-Abl shows both cytoplasmic and nuclear localization, c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.

27

P42684

P42684

Human

Ni-NTA purified truncated recombinant ABL2 expressed in E. Coli strain BL21 (DE3) .

1H1B11

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

ABL2 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

ABL2

C-abl oncogene 2, non-receptor tyrosine kinase

Homo sapiens

Yoshimi I, Takashi I, Tsuneyuki O, et al. Blood. 2000; 95 (6) : 2126-2131.

Scheijen, B. and Griffin, J.D. Oncogene. 2002) ; 21 3314-33.

ABLL, ARG, Abelson murine leukemia viral oncogene homolog 2ARG, ABLL

ELISA, WB, IF

1168268