ABS-752

ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 has the potential for the research of hepatocellular carcinoma[1].

2761170-84-5

12352005

H302-H315-H319-H335

Molecular Glues; NEKs

Cell Cycle/DNA Damage; PROTAC

Cancer-programmed cell death

Cancer

O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O

C14H14FN3O3

291.28

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Przemysław Glaza, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC. Biorxiv. 2025.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W599279/

Reference compound1

No Development Reported