ABS-752 (hydrochloride)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ABS-752 is an orally active prodrug of CRBN-modulating molecular glue targeting. ABS-752 can effectively degrade GSPT1. ABS-752 can degrade NEK7. ABS-752 does not form ternary complexes with CRBN and the neosubstrates. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 can be used for the study of hepatocellular carcinoma (HCC) [1].
2922884-90-8
12352005
H302-H315-H319-H335
Molecular Glues; NEKs
Cell Cycle/DNA Damage; PROTAC
Cancer-programmed cell death
Cancer
O=C1C2=CC(F)=C(CN)C=C2CN1C3C(NC(CC3)=O)=O.Cl
C14H15ClFN3O3
327.74
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Glaza P, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC. Commun Chem. 2025 Aug 14;8 (1) :247.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W998347/
Reference compound1
No Development Reported
NEK7
Beschrijving
ABS-752 is an orally active prodrug of CRBN-modulating molecular glue targeting. ABS-752 can effectively degrade GSPT1. ABS-752 can degrade NEK7. ABS-752 does n
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