Ac-DMLD-CMK
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2588354-33-8
Caspase, Pyroptosis
Proteases/Proteasome, Immunology/Inflammation, Apoptosis
Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.
[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)(NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CCSC)=O)CC(C)C
C22H35ClN4O9S
567.053
Ice Packs
-20°C
Beschrijving
Ac-DMLD-CMK Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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