Ac-MRGDH-NH2

Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. Ac-MRGDH-NH2 can be used to synthesize the diastereoisomeric prodrugs Λ- and Δ-[Ru (Ph2phen) 2 (κS, κN- (Ac-MRGDH-NH2) ) ]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic bis-aqua ruthenium warhead [Ru (Ph2phen) 2 (OH2) 2]2+, and Ac-MRGDH-NH2 possesses integrin targeting ability and photosubstitution properties. Therefore, Ac-MRGDH-NH2 can be utilized in research on tumor-targeted photodynamic activation chemotherapy (PACT) [1].

12352209

Integrin

Cytoskeleton

Cancer-programmed cell death

Cancer

O=C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N)=O)=O)=O)=O)=O)C

C25H41N11O8S

655.73

[1]Zhang L, et al. Cyclic ruthenium-peptide conjugates as integrin-targeting phototherapeutic prodrugs for the treatment of brain tumors[J]. Journal of the American Chemical Society, 2023, 145 (27) : 14963-14980.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10667/

Peptides

No Development Reported