Ac4GlcNAz

Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC) . It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu (I) -catalyzed azide-alkyne cycloaddition conditions.

98924-81-3

N-azidoacetylglucosamine-tetraacylated

12352005

H302, H315, H319, H335

Biochemical Assay Reagents

Others

Others

99.60

DMSO : 100 mg/mL (ultrasonic)

CC(O[C@@H]1[C@H](C(O[C@@H]([C@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CN=[N+]=[N-])=O)=O

C16H22N4O10

430.37

H302, H315, H319, H335

[1]Luong P, Ghosh A, Moulton KD, Kulkarni SS, Dube DH. Synthesis and Application of Rare Deoxy Amino l-Sugar Analogues to Probe Glycans in Pathogenic Bacteria. ACS Infect Dis. 2022 Apr 8;8 (4) :889-900. |[2]Clark EL, Emmadi M, Krupp KL, Podilapu AR, Helble JD, Kulkarni SS, Dube DH. Development of Rare Bacterial Monosaccharide Analogs for Metabolic Glycan Labeling in Pathogenic Bacteria. ACS Chem Biol. 2016 Dec 16;11 (12) :3365-3373.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W039953/Ac4GlcNAz-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported