ACC1, Monoklonale Antilichaam

This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen Type II. The antibody binds to flexible triple-helical Collagen Type II determinants and many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native Collagen Type II. It cross-reacts with mouse and human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs) . Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.

This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen...

ACC1, Monoclonal Antibody, 100ug

COL2A1, Collagen Type II, Collagen alpha-1 (II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins.

Mouse, Human

B10.RIII Cia5 congenic mouse immunized with Bovine Collagen Type II

ACC1

Immunohistochemistry (IHC), ELISA, bead-based multiplex immunoassay

Antibodies

It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100 and ELISA 1:200-1:500.

This antibody is soluble and supplied in PBS.

Mouse IgG2a, k