ACC4 (IgG2b), Monoklonale Antilichaam

This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369) . It cross-reacts with mouse, bovine, and potentially human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs) . Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.

This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369) . It cross-reacts with mouse, bovine, and potentially...

ACC4 (IgG2b), Monoclonal Antibody, 100ug

Mouse, Human, potentially Human

Generated by immunization of DBA/1 or (B10.Q x DBA/1) F1 mice with Protein- arginine deiminase type-4 (PAD4) -treated triple-helical CII peptides containing T and B cell epitopes.

ACC4

Immunohistochemistry (IHC), in-vivo functional studies such Collagen- Induced Arthritis (CIA), and evoked pain-behavior

Antibodies

It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100.

This antibody is soluble and supplied in PBS.

Mouse IgG2b, k