ACDN4 Antilichaam

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

81

O43707

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 570-650 of human ACTN4 (NP_004915.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Immunology, Signal Transduction

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 105kDa

IgG

ACTN4

HepG2

Raji

Mouse liver

Mouse kidney

Mouse heart

Actinin, alpha 4

Homo sapiens

ACTN4, DKFZp686K23158, FSGS, FSGS1, ACTININ-4

WB, IF

Liquid