ACE2 Antilichaam

COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans

59272

Q9BYF1

NP_068576

Human, Mouse, Rat

3215

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar ACE2 expression profile in human cell lines detected by three independent anti-ACE2 antibodies that recognize different epitopes, 3215 against central domain, 3217 against C-terminus domain and 3227 against N-terminus domain. ACE2 proteins are detected in the most tested tissues at different expression levels by three independent antibodies. Independent Antibody Validation in Cell lines3215 32173227

Infectious Disease

ACE2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Anti-ACE2 has no cross response to ACE1.

Human ACE2 has 2 isoforms, including isoform 1 (805aa, 93kD) and isoform 2 (555aa, 64kD) . Mouse ACE2 also has 2 isoforms, including isoform 1 (805aa, 92kD) and isoform 2 (353aa, 40kD) . Rat ACE2 has one isoform (805aa, 93kD) . 3215 can detect human, mouse and rat.

ACE2

Cat. No. 10-401 - Human Kidney Tissue Slide

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 1313 - Human Testis Tissue Lysate

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Homo sapiens

Donoghue et al. Circ. Res. 2000;87:1-9.

Tipnis et al. J Biol. Chem. 2000;275:33238-43.

Li et al. Nature 2003;426:450-4.

Lu et al. The Lancet 2020 (published online) .

Crackower et al. Nature 2002;417:822-8.

ACE2 Antibody: ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, SARS-CoV receptor, SARS-CoV-2 receptor

ELISA, WB, IHC-P, IF

11225609

Liquid