Acetoacetyl-CoA (natriumhydraat)

Acetoacetyl CoA sodium hydrate is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA sodium hydrate from two acetyl-CoA molecules. Acetoacetyl CoA sodium hydrate is essential for cholesterol biosynthesis. Acetoacetyl-CoA sodium hydrate is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3].

3-Oxobutanoyl-coenzyme A (sodium hydrate)

12352100

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolism-sugar/lipid metabolism

Metabolic Disease

97

H2O : 50 mg/mL (ultrasonic)

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32.[x].[Na].O.[x]

[1]Miziorko HM. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys. 2011 Jan 15;505 (2) :131-43.|[2]Liu L, et al. Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula. Front Microbiol. 2020 Mar 11;11:354.|[3] Feodor Lynen, et al. Enzymes of fatty acid metabolism. Biochimica et Biophysica Acta. Volume 12, Issues 1-2, October 1953, Pages 299-314.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-N7392A/Acetoacetyl-CoA-sodium-hydrate-SDS-MedChemExpress.pdf

Natural Products

No Development Reported

Human Endogenous Metabolite