ACI-3024
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases[1].
2361566-66-5
12352005
Tau Protein
Neuronal Signaling
Neurological Disease
FC=1C=CC2=C(C1)NC3=C2CN(C=4C=CC=5OC(=NC5C4)N6CCOCC6)CC3
C22H21FN4O2
392.43
[1]Nisbet R M, et al. O5‐06‐04: CHARACTERIZATION OF NOVEL TAU‐SPECIFIC ANTIBODIES AND ENHANCEMENT OF THEIR DELIVERY INTO THE BRAIN USING FOCUSED SCANNING ULTRASOUND[J]. Alzheimer's & Dementia, 2019, 15: P1629-P1630.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W835959/
Reference compound1
No Development Reported
Beschrijving
ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of patholog
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