Acivicin (hydrochloride) (standaard)

Acivicin (hydrochloride) (Standard) is the analytical standard of Acivicin (hydrochloride) . This product is intended for research and analytical applications. Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

161922-40-3

AT-125 (hydrochloride) (Standard) ; U-42126 (hydrochloride) (Standard)

12352005

Parasite; Reference Standards; γ-Glutamyl Transferase (GGT)

Anti-infection; Metabolic Enzyme/Protease; Others

Cancer; Infection

[H]Cl.ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1

C5H8Cl2N2O3

215.03

[1]Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30 (3) :154-60.|[2]Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6 (1) :237-245. Epub 2014 Sep 26.|[3]Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49 (7) :941-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W016586AR/

Reference Standards