Act3 Antilichaam [3B12F3F10 / 2D2B11B11 / 2D2B11H5]

Akt3 (also designated protein kinase B gamma or v-akt murine thymoma viral oncogene homolog 3), with 479-amino acid protein (about 53 kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt2. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.Akt3 is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. Identifying Akt3 as a selective target in melanoma cells also provides new therapeutic opportunities for patients in the advanced stages of this disease.

10000

Q9Y243

Q9Y243

Human

Ni-NTA purified truncated recombinant Akt3 expressed in E. Coli strain BL21 (DE3) .

3B12F3F10 / 2D2B11B11 / 2D2B11H5

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Akt3 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

AKT3

V-akt murine thymoma viral oncogene homolog 3

Homo sapiens

Rachael M. Easton, Han Cho, Kristin Roovers. Mol. Cell. Biol., Mar 2005; 25: 1869 – 1878.

Jill M. Stahl, Arati Sharma, Mitchell Cheung. Cancer Res., Oct 2004; 64: 7002–7010.

PKBG, Protein kinase Akt-3, PKB gamma, MPPH, PKBG, PRKBG, STK-2, PKB-GAMMA, RAC-gamma, RAC-PK-gamma

ELISA, WB

12643943